The sciatic nerve exits the spinal column between the lowest lumbar vertebral body (L5) and first level of the sacrum (S1). It supplies sensation to the posterior thigh and buttock, knee flexors, and foot muscles. When this nerve is compressed, inflamed, or irritated anywhere along its length, pain may result. The term sciatica refers to pain radiating down the sciatic nerve into the posterior thigh, leg, and little toe, mostly due to nerve root irritation in the spinal column.
